With Google owning VirusTotal and having Google Project Zero, I’m surprised Google doesn’t have its own equivalent to Windows Defender. AFAIK, Play Protect isn’t really that good at spotting malicious apps.
Microsoft Defender for Android (through Microsoft 365) is there for anyone paying for 365. IIRC, T-Mobile customers get Lookout Premium for free.
No, it won’t be blocked.
That being said, it will be handicapped.
https://www.spacebar.news/chrome-ad-blocking-manifest-v3-ublock-origin/
Safari doesn’t have uBlock Origin at the moment AFAIK; it was discontinued. uBlock Origin on Firefox will continue using MV2 which allows for better extension/list updating.