There doesn’t need to be more to it than that. The observable universe is over 93 billion light years in diameter. That means even at the speed of light, it would take over 6.5x longer than the universe has even existed for anything to cross that distance… except the universe is expanding faster than the speed of light, so actually you need to go significantly faster than light to make it across. FTL is, sadly, still firmly in the realm of science fiction, so to the best of our current knowledge most of the universe is permanently inaccessible.
Sure, that’s an option. It doesn’t really change my overall point though that anything beyond galactic colonization is unrealistic on any time scale. Our next nearest neighbor, the Andromeda Galaxy, is over 2.5 MILLION light years away, over 10 times farther than my “crossing the milky way” example, with nothing in-between to make a pit stop if needed, you have to cross the true void of space to get there.
And that’s just to get the next nearest galaxy. Current estimates suggest the observable universe contains 2 TRILLION galaxies.